Germ cell tumors in the brain are rare and account for about 4% of brain tumors diagnosed in children.  They are commonly diagnosed during adolescence and affect boys more than girls.  Germ cell tumors can spread to other parts of the brain and spinal cord but originate in the center of the brain around the suprasellar and pineal regions.

Symptoms of suprasellar tumors present themselves with hormonal problems, while pineal region germ cell tumors cause increased pressure with headaches and vomiting.

Prognosis for a type of germ cell tumor called germinoma is extremely high, with about 85% of patients being cured through radiation therapy alone.

Other types of germ cell tumors are less sensitive to radiation where cure rates are only about 20%.